Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice : Evidence in Support of a Role for Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3 in Lesion Development and Hepatic Steatosis

We have previously shown that glucosamine promotes endoplasmic reticulum (ER) stress in vascular cells leading to both inflammation and lipid accumulation—the hallmark features of atherosclerosis. Pretreatment with glycogen synthase kinase (GSK)-3 inhibitors protects cultured cells from ER stress-in...

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Detalhes bibliográficos
Main Authors: Bowes, Anna J., Khan, Mohammad I., Shi, Yuanyuan, Robertson, Lindsie, Werstuck, Geoff H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631345/
https://ncbi.nlm.nih.gov/pubmed/19095952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080385
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