Activin C Antagonizes Activin A in Vitro and Overexpression Leads to Pathologies in Vivo

Activin A is a potent growth and differentiation factor whose synthesis and bioactivity are tightly regulated. Both follistatin binding and inhibin subunit heterodimerization block access to the activin receptor and/or receptor activation. We postulated that the activin-β(C) subunit provides another...

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Autori principali: Gold, Elspeth, Jetly, Niti, O'Bryan, Moira K., Meachem, Sarah, Srinivasan, Deepa, Behuria, Supreeti, Sanchez-Partida, L. Gabriel, Woodruff, Teresa, Hedwards, Shelley, Wang, Hong, McDougall, Helen, Casey, Victoria, Niranjan, Birunthi, Patella, Shane, Risbridger, Gail
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2009
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631331/
https://ncbi.nlm.nih.gov/pubmed/19095948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080296
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