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PIM-1–specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis

Provirus integration site for Moloney murine leukemia virus (PIM1) is a proto-oncogene that encodes a serine/threonine kinase with multiple cellular functions. Overexpression of PIM-1 plays a critical role in progression of prostatic and hematopoietic malignancies. Here we describe the generation of...

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Bibliografische gegevens
Hoofdauteurs: Hu, Xiu Feng, Li, Jie, Vandervalk, Scott, Wang, Zeping, Magnuson, Nancy S., Xing, Pei Xiang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631288/
https://ncbi.nlm.nih.gov/pubmed/19147983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33216
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