Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-β1

In clinical trials recombinant-modified vaccinia virus Ankara expressing the Mycobacterium tuberculosis antigen 85A (MVA85A) induces approximately 10 times more effector T cells than any other recombinant MVA vaccine. We have found that in BCG primed subjects MVA85A vaccination reduces transforming...

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Main Authors: Fletcher, Helen A., Pathan, Ansar A., Berthoud, Tamara K., Dunachie, Susanna J., Whelan, Kathryn T., Alder, Nicola C., Sander, Clare R., Hill, Adrian V.S., McShane, Helen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631167/
https://ncbi.nlm.nih.gov/pubmed/18682270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.07.040
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