Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP

Folate derivatives are essential vitamins for cell growth and replication, primarily because of their central role in reactions of one-carbon metabolism. Folates require polyglutamation to be efficiently retained within the cell and folate-dependent enzymes have a higher affinity for the polyglutamy...

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Bibliografiska uppgifter
Huvudupphovsmän: Young, Paul G., Smith, Clyde A., Metcalf, Peter, Baker, Edward N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2008
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631112/
https://ncbi.nlm.nih.gov/pubmed/18566510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444908012262
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