Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target

BACKGROUND: Angiostatin, an endogenous angiogenesis inhibitor, is a fragment of plasminogen. Its anti-angiogenic activity was discovered with functional assays in vivo, however, its direct action on endothelial cells is moderate and identification of definitive mechanisms of action has been elusive...

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Bibliografiske detaljer
Main Authors: Albini, Adriana, Brigati, Claudio, Ventura, Agostina, Lorusso, Girieca, Pinter, Marta, Morini, Monica, Mancino, Alessandra, Sica, Antonio, Noonan, Douglas M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630934/
https://ncbi.nlm.nih.gov/pubmed/19144161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-7-5
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