The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin

Angiostatin, a potent naturally occurring inhibitor of angiogenesis and growth of tumor metastases, is generated by cancer-mediated proteolysis of plasminogen. Human prostate carcinoma cells (PC-3) release enzymatic activity that converts plasminogen to angiostatin. We have now identified two compon...

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Detalhes bibliográficos
Main Authors: Gately, Stephen, Twardowski, Przemyslaw, Stack, M. Sharon, Cundiff, Deborah L., Grella, Davida, Castellino, Francis J., Enghild, Jan, Kwaan, Hau C., Lee, Francis, Kramer, Robert A., Volpert, Olga, Bouck, Noel, Soff, Gerald A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC23512/
https://ncbi.nlm.nih.gov/pubmed/9380726
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