Testosterone Supplementation in Older Men Restrains Insulin-Like Growth Factor’s Dose-Dependent Feedback Inhibition of Pulsatile Growth Hormone Secretion

Background: Pulsatile GH secretion declines in older men. The causal mechanisms are unknown. Candidates include deficient feedforward (stimulation) by endogenous secretagogues and excessive feedback (inhibition) by GH or IGF-I due to age and/or relative hypoandrogenemia. Hypothesis: Testosterone (T)...

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Detalhes bibliográficos
Main Authors: Veldhuis, Johannes D., Keenan, Daniel M., Bailey, Joy N., Adeniji, Adenborduin, Miles, John M., Paulo, Remberto, Cosma, Mihaela, Soares-Welch, Cacia
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630862/
https://ncbi.nlm.nih.gov/pubmed/18984660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2008-1516
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