Aromatase and 5α-Reductase Inhibition during an Exogenous Testosterone Clamp Unveils Selective Sex Steroid Modulation of Somatostatin and Growth Hormone Secretagogue Actions in Healthy Older Men

Background: How endogenous testosterone (Te), 5α-dihydrotestosterone (DHT), and estradiol (E(2)) regulate pulsatile GH secretion is not understood. Hypothesis: Conversion of Te to androgenic (Te→DHT) or estrogenic (Te→E(2)) products directs GH secretion. Subjects and Location: Healthy older men (N =...

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Detalhes bibliográficos
Main Authors: Veldhuis, Johannes D., Mielke, Kristi L., Cosma, Mihaela, Soares-Welch, Cacia, Paulo, Remberto, Miles, John M., Bowers, Cyril Y.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681279/
https://ncbi.nlm.nih.gov/pubmed/19088159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2008-2108
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