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Activity of the Oral Neuraminidase Inhibitor A-322278 against the Oseltamivir-Resistant H274Y (A/H1N1) Influenza Virus Mutant in Mice

The new oral neuraminidase (NA) inhibitor A-322278 was evaluated in mice infected with influenza A/H1N1 wild-type virus or the oseltamivir-resistant (H274Y mutant) virus. A-322278 decreased mortality rates and lung virus titers significantly more than oseltamivir in mice infected with the NA H274Y m...

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Detalhes bibliográficos
Main Authors: Baz, Mariana, Abed, Yacine, Nehmé, Benjamin, Boivin, Guy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630661/
https://ncbi.nlm.nih.gov/pubmed/19015327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01276-08
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