Intrapulmonary Pharmacokinetics and Pharmacodynamics of Posaconazole at Steady State in Healthy Subjects

We evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of posaconazole (POS) in a prospective, open-label study. Twenty-five healthy adults received 14 doses of POS oral suspension (400 mg twice daily) with a high-fat meal over 8 days. Pulmonary epithelial lining fluid (ELF) and alveolar c...

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Bibliographic Details
Main Authors: Conte, John E., Golden, Jeffrey A., Krishna, Gopal, McIver, Marina, Little, Emily, Zurlinden, Elisabeth
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630621/
https://ncbi.nlm.nih.gov/pubmed/19029316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00663-08
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