EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

Trimethylation on H3K27 (H3K27me3) mediated by the Polycomb repressive complex 2 (PRC2) has been linked to embryonic stem (ES) cell identity and pluripotency. EZH2, the catalytic subunit of PRC2, has been reported as the sole histone methyltransferase which methylates H3K27 and mediates transcriptio...

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Detalhes bibliográficos
Principais autores: Shen, Xiaohua, Liu, Yingchun, Hsu, Yu-Jung, Fujiwara, Yuko, Kim, Jonghwan, Mao, Xiaohong, Yuan, Guo-Cheng, Orkin, Stuart H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630502/
https://ncbi.nlm.nih.gov/pubmed/19026780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.10.016
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