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A quantitative trait locus on chr.4 affects cycling of hematopoietic stem and progenitor cells through regulation of transforming growth factor-beta 2 responsiveness
The hematopoietic stem and progenitor cell (HSPC) compartment is subject to extensive quantitative genetic variation. We have previously shown that transforming growth factor-beta 2 (TGF-β2) at low concentrations enhances flt3 ligand induced growth of HSPCs, while it is potently antiproliferative at...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630176/ https://ncbi.nlm.nih.gov/pubmed/18941179 |
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