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The Adaptor Molecule SAP Regulates IFNγ and IL-4 Production in Vα14 Transgenic NKT cells via Effects on GATA-3 and T-bet Expression
NKT cells comprise a rare regulatory T cell population of limited TCR diversity, with most cells utilizing a Vα14Jα18 TCR. These cells exhibit a critical dependence on the signaling adapter molecule SAP for their ontogeny, an aspect not seen in conventional αβ T cells. Prior studies demonstrate that...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630172/ https://ncbi.nlm.nih.gov/pubmed/19155483 |
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