Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors

PURPOSE: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation of the von Hippel-Lindau VHL gene in the cancer genome, unique to clear cell renal cancer (ccRCC). Identify relationships between the prevalence of VHL gene alterations and alteration subtypes wi...

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Autores principales: Nickerson, Michael L., Jaeger, Erich, Shi, Yangu, Durocher, Jeffrey A., Mahurkar, Sunil, Zaridze, David, Matveev, Vsevolod, Janout, Vladimir, Kollarova, Hellena, Bencko, Vladimir, Navratilova, Marie, Szeszenia-Dabrowska, Neonilia, Mates, Dana, Mukeria, Anush, Holcatova, Ivana, Schmidt, Laura S., Toro, Jorge R., Karami, Sara, Hung, Rayjean, Gerard, Gary F., Linehan, W. Marston, Merino, Maria, Zbar, Berton, Boffetta, Paolo, Brennan, Paul, Rothman, Nathaniel, Chow, Wong-Ho, Waldman, Frederic M., Moore, Lee E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629664/
https://ncbi.nlm.nih.gov/pubmed/18676741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-4921
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