Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants

Trichloroethylene (TCE) is a suspected renal carcinogen. TCE-associated renal genotoxicity occurs predominantly through glutathione S-transferase (GST) conjugation and bioactivation by renal cysteine beta-lyase (CCBL1). We conducted a case-control study in Central Europe (1,097 cases/1,476 controls)...

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Main Authors: Moore, Lee E., Boffetta, Paolo, Karami, Sara, Brennan, Paul, Stewart, Patricia S, Hung, Rayjean, Zaridze, David, Matveev, Vsevolod, Janout, Vladimir, Kollarova, Helena, Bencko, Vladimir, Navratilova, Marie, Szeszenia-Dabrowska, Neonila, Mates, Dana, Gromiec, Jan, Holcatova, Ivana, Merino, Maria, Chanock, Stephen, Chow, Wong-Ho, Rothman, Nathaniel
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922418/
https://ncbi.nlm.nih.gov/pubmed/20663906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4167
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