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Bax targeting to mitochondria occurs via both tail anchor dependent and independent mechanisms
Bax is a member of the Bcl-2 family that, together with Bak, is required for permeabilisation of the outer mitochondrial membrane (OMM). Bax differs from Bak in that it is predominantly cytosolic in healthy cells and only associates with the OMM after an apoptotic signal. How Bax is targeted to the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629617/ https://ncbi.nlm.nih.gov/pubmed/18437166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.39 |
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