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Bax targeting to mitochondria occurs via both tail anchor dependent and independent mechanisms

Bax is a member of the Bcl-2 family that, together with Bak, is required for permeabilisation of the outer mitochondrial membrane (OMM). Bax differs from Bak in that it is predominantly cytosolic in healthy cells and only associates with the OMM after an apoptotic signal. How Bax is targeted to the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Valentijn, Anthony J., Upton, John-Paul, Bates, Nicola, Gilmore, Andrew P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629617/
https://ncbi.nlm.nih.gov/pubmed/18437166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.39
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