EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance

Aberrant activation of the androgen receptor (AR) by the ErbB2/ErbB3 heterodimer contributes to the development of hormone resistance in prostate cancer. EBP1, an ErbB3-binding protein, acts as an AR corepressor. As EBP1 is decreased in preclinical models of hormone-refractory prostate cancer, we st...

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Bibliografiske detaljer
Main Authors: Zhang, Yuexing, Linn, Douglas, Liu, Zhenqiu, Melamed, Jonathan, Tavora, Fabio, Young, Charles Y., Burger, Angelika M., Hamburger, Anne W.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629587/
https://ncbi.nlm.nih.gov/pubmed/18852121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0526
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