The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells

Down-regulation of the androgen receptor (AR) is being evaluated as an effective therapy for the advanced stages of prostate cancer. We report that Ebp1, a protein identified by its interactions with the ErbB3 receptor, down-regulates expression of AR and AR-regulated genes in the LNCaP prostate can...

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Bibliographic Details
Main Authors: Zhang, Yuexing, Wang, Xin-Wei, Jelovac, Danijela, Nakanishi, Takeo, Yu, Myoung-hee, Akinmade, Damilola, Goloubeva, Olga, Ross, Douglas D., Brodie, Angela, Hamburger, Anne W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175001/
https://ncbi.nlm.nih.gov/pubmed/15994225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503829102
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