Liver Cancer-Derived Hepatitis C Virus Core Proteins Shift TGF-Beta Responses from Tumor Suppression to Epithelial-Mesenchymal Transition

BACKGROUND: Chronic hepatitis C virus (HCV) infection and associated liver cirrhosis represent a major risk factor for hepatocellular carcinoma (HCC) development. TGF-β is an important driver of liver fibrogenesis and cancer; however, its actual impact in human cancer progression is still poorly kno...

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Autori principali: Battaglia, Serena, Benzoubir, Nassima, Nobilet, Soizic, Charneau, Pierre, Samuel, Didier, Zignego, Anna Linda, Atfi, Azeddine, Bréchot, Christian, Bourgeade, Marie-Françoise
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629560/
https://ncbi.nlm.nih.gov/pubmed/19190755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004355
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