DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms and enzymes remain unclear. Using zebrafish embryos we provide evidence for 5-methylcytosine (5-meC) removal in vivo via the coupling of a 5-meC deaminase (AID, which converts 5-meC to thymine) and a G:T mismatc...

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Main Authors: Rai, Kunal, Huggins, Ian J., James, Smitha R., Karpf, Adam R., Jones, David A., Cairns, Bradley R.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629358/
https://ncbi.nlm.nih.gov/pubmed/19109892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.11.042
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