A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity

A conundrum of innate antiviral immunity is how nucleic acid-sensing Toll-like receptors (TLRs) and RIG-I/MDA5 receptors cooperate during virus infection. The conventional wisdom has been that the activation of these receptor pathways evokes type I IFN (IFN) responses. Here, we provide evidence for...

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Detalhes bibliográficos
Main Authors: Negishi, Hideo, Osawa, Tomoko, Ogami, Kentaro, Ouyang, Xinshou, Sakaguchi, Shinya, Koshiba, Ryuji, Yanai, Hideyuki, Seko, Yoshinori, Shitara, Hiroshi, Bishop, Keith, Yonekawa, Hiromichi, Tamura, Tomohiko, Kaisho, Tsuneyasu, Taya, Choji, Taniguchi, Tadatsugu, Honda, Kenya
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629334/
https://ncbi.nlm.nih.gov/pubmed/19074283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810372105
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