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Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases

Cyclooxygenase (COX-1/COX-2)-catalyzed eicosanoid formation plays a key role in inflammation-associated diseases. Natural forms of vitamin E are recently shown to be metabolized to long-chain carboxychromanols and their sulfated counterparts. Here we find that vitamin E forms differentially inhibit...

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Detalhes bibliográficos
Main Authors: Jiang, Qing, Yin, Xinmin, Lill, Markus A., Danielson, Matthew L., Freiser, Helene, Huang, Jianjie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629323/
https://ncbi.nlm.nih.gov/pubmed/19074288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810962106
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