PKCη regulates occludin phosphorylation and epithelial tight junction integrity

PKCη is expressed predominantly in the epithelial tissues; however, its role in the regulation of epithelial tight junctions (TJs) is unknown. We present evidence that PKCη phosphorylates occludin on threonine residues (T403 and T404) and plays a crucial role in the assembly and/or maintenance of TJ...

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Autori principali: Suzuki, Takuya, Elias, Bertha C., Seth, Ankur, Shen, Le, Turner, Jerrold R., Giorgianni, Francesco, Desiderio, Dominic, Guntaka, Ramareddy, Rao, Radhakrishna
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629239/
https://ncbi.nlm.nih.gov/pubmed/19114660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802741106
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