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PKCη regulates occludin phosphorylation and epithelial tight junction integrity
PKCη is expressed predominantly in the epithelial tissues; however, its role in the regulation of epithelial tight junctions (TJs) is unknown. We present evidence that PKCη phosphorylates occludin on threonine residues (T403 and T404) and plays a crucial role in the assembly and/or maintenance of TJ...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629239/ https://ncbi.nlm.nih.gov/pubmed/19114660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802741106 |
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