Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

In a search for more effective anti-diabetic treatment, we used a process coupling low-affinity biochemical screening with high-throughput co-crystallography in the design of a series of compounds that selectively modulate the activities of all three peroxisome proliferator-activated receptors (PPAR...

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Detalhes bibliográficos
Main Authors: Artis, Dean R., Lin, Jack J., Zhang, Chao, Wang, Weiru, Mehra, Upasana, Perreault, Mylene, Erbe, David, Krupka, Heike I., England, Bruce P., Arnold, James, Plotnikov, Alexander N., Marimuthu, Adhirai, Nguyen, Hoa, Will, Sarah, Signaevsky, Maxime, Kral, John, Cantwell, John, Settachatgull, Calvin, Yan, Douglas S., Fong, Daniel, Oh, Angela, Shi, Shenghua, Womack, Patrick, Powell, Benjamin, Habets, Gaston, West, Brian L., Zhang, Kam Y. J., Milburn, Michael V., Vlasuk, George P., Hirth, K. Peter, Nolop, Keith, Bollag, Gideon, Ibrahim, Prabha N., Tobin, James F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629228/
https://ncbi.nlm.nih.gov/pubmed/19116277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811325106
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