Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase

Protein kinases are a large family of cell signaling mediators undergoing intensive research to identify inhibitors or modulators useful for medicine. As one strategy, small-molecule compounds that bind the active site with high affinity can be used to inhibit the enzyme activity. X-ray crystallogra...

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Bibliografiske detaljer
Main Authors: Wang, Weiru, Marimuthu, Adhirai, Tsai, James, Kumar, Abhinav, Krupka, Heike I., Zhang, Chao, Powell, Ben, Suzuki, Yoshihisa, Nguyen, Hoa, Tabrizizad, Maryam, Luu, Catherine, West, Brian L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450123/
https://ncbi.nlm.nih.gov/pubmed/16537444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600048103
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