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Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase
Protein kinases are a large family of cell signaling mediators undergoing intensive research to identify inhibitors or modulators useful for medicine. As one strategy, small-molecule compounds that bind the active site with high affinity can be used to inhibit the enzyme activity. X-ray crystallogra...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1450123/ https://ncbi.nlm.nih.gov/pubmed/16537444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600048103 |
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