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The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations

Characterization of the molecular pathways that are required for the viability and maintenance of self-renewing tumor-initiating cells may ultimately lead to improved therapies for cancer. In this study, we show that a CD133(+)/CD44(+) population of cells enriched in prostate cancer progenitors (PCa...

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Detalhes bibliográficos
Main Authors: Dubrovska, Anna, Kim, Sungeun, Salamone, Richard J., Walker, John R., Maira, Sauveur-Michel, García-Echeverría, Carlos, Schultz, Peter G., Reddy, Venkateshwar A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629188/
https://ncbi.nlm.nih.gov/pubmed/19116269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810956106
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