A class frequency mixture model that adjusts for site-specific amino acid frequencies and improves inference of protein phylogeny

BACKGROUND: Widely used substitution models for proteins, such as the Jones-Taylor-Thornton (JTT) or Whelan and Goldman (WAG) models, are based on empirical amino acid interchange matrices estimated from databases of protein alignments that incorporate the average amino acid frequencies of the data...

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Main Authors: Wang, Huai-Chun, Li, Karen, Susko, Edward, Roger, Andrew J
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Methodology Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628903/
https://ncbi.nlm.nih.gov/pubmed/19087270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-8-331
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