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A class frequency mixture model that adjusts for site-specific amino acid frequencies and improves inference of protein phylogeny

BACKGROUND: Widely used substitution models for proteins, such as the Jones-Taylor-Thornton (JTT) or Whelan and Goldman (WAG) models, are based on empirical amino acid interchange matrices estimated from databases of protein alignments that incorporate the average amino acid frequencies of the data...

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Hlavní autoři: Wang, Huai-Chun, Li, Karen, Susko, Edward, Roger, Andrew J
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628903/
https://ncbi.nlm.nih.gov/pubmed/19087270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-8-331
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