Functional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'–5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch

ABSTRACT: Maelstrom (MAEL) plays a crucial role in a recently-discovered piRNA pathway; however its specific function remains unknown. Here a novel MAEL-specific domain characterized by a set of conserved residues (Glu-His-His-Cys-His-Cys, EHHCHC) was identified in a broad range of species including...

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Bibliographic Details
Main Authors: Zhang, Dapeng, Xiong, Huiling, Shan, Jufang, Xia, Xuhua, Trudeau, Vance L
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628886/
https://ncbi.nlm.nih.gov/pubmed/19032786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-3-48
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