Recognition of Human Proinsulin Leader Sequence by Class I–Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes

OBJECTIVE— A restricted region of proinsulin located in the B chain and adjacent region of C-peptide has been shown to contain numerous candidate epitopes recognized by CD8(+) T-cells. Our objective is to characterize HLA class I–restricted epitopes located within the preproinsulin leader sequence....

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Autori principali: Toma, Andréa, Laïka, Taghrid, Haddouk, Samy, Luce, Sandrine, Briand, Jean-Paul, Camoin, Luc, Connan, Francine, Lambert, Marion, Caillat-Zucman, Sophie, Carel, Jean-Claude, Muller, Sylviane, Choppin, Jeannine, Lemonnier, François, Boitard, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2009
Soggetti:
Immunology and Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628613/
https://ncbi.nlm.nih.gov/pubmed/19011169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0599
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