Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity

Recombinant interleukin-2 (IL-2) therapy for malignancy is associated with a pulmonary vascular leakage syndrome (VLS) similar to that seen in sepsis. We investigated the possibility that the IL-2-induced VLS may be associated with the release of peroxynitrite (ONOO(−)), and used a model of IL-2-ind...

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Hauptverfasser: Maybauer, Dirk M., Maybauer, Marc O., Szabó, Csaba, Westphal, Martin, Traber, Lillian D., Enkhbataar, Perenlei, Murthy, Kanneganti G. K., Nakano, Yoshimitsu, Salzman, Andrew, Herndon, David N., Traber, Daniel L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628331/
https://ncbi.nlm.nih.gov/pubmed/18951875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.10.066
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