Retinoic Acid Receptor α Fusion to PML Affects Its Transcriptional and Chromatin-Remodeling Properties

PML-RAR is an oncogenic transcription factor forming in acute promyelocytic leukemias (APL) because of a chromosomal translocation. Without its ligand, retinoic acid (RA), PML-RAR functions as a constitutive transcriptional repressor, abnormally associating with the corepressor-histone deacetylase c...

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Detalhes bibliográficos
Main Authors: Segalla, Simona, Rinaldi, Laura, Kilstrup-Nielsen, Charlotte, Badaracco, Gianfranco, Minucci, Saverio, Pelicci, Pier Giuseppe, Landsberger, Nicoletta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262687/
https://ncbi.nlm.nih.gov/pubmed/14612419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.23.8795-8808.2003
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