Fibrillarin Is Essential for Early Development and Required for Accumulation of an Intron-Encoded Small Nucleolar RNA in the Mouse

Fibrillarin, a protein component of C/D box small nucleolar ribonucleoproteins (snoRNPs), directs 2′-O-methylation of rRNA and is also involved in other aspects of rRNA processing. A gene trap screen in embryonic stem (ES) cells resulted in an insertion mutation in the fibrillarin gene. This inserti...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Newton, Kathryn, Petfalski, Elisabeth, Tollervey, David, Cáceres, Javier F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262675/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14612397/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.23.8519-8527.2003
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