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Fibrillarin Is Essential for Early Development and Required for Accumulation of an Intron-Encoded Small Nucleolar RNA in the Mouse

Fibrillarin, a protein component of C/D box small nucleolar ribonucleoproteins (snoRNPs), directs 2′-O-methylation of rRNA and is also involved in other aspects of rRNA processing. A gene trap screen in embryonic stem (ES) cells resulted in an insertion mutation in the fibrillarin gene. This inserti...

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Udgivet i:Mol Cell Biol
Principais autores: Newton, Kathryn, Petfalski, Elisabeth, Tollervey, David, Cáceres, Javier F.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262675/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14612397/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.23.8519-8527.2003
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