The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity

Histone deacetylase 4 (HDAC4) binds and inhibits activation of the critical muscle transcription factor myocyte enhancer factor-2 (MEF2). However, the physiological significance of the HDAC4-MEF2 complex in skeletal muscle has not been established. Here we show that in skeletal muscle, HDAC4 is a cr...

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Detalhes bibliográficos
Main Authors: Cohen, Todd J., Barrientos, Tomasa, Hartman, Zachary C., Garvey, Sean M., Cox, Gregory A., Yao, Tso-Pang
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626618/
https://ncbi.nlm.nih.gov/pubmed/18780762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-115931
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