Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium

Diarrhea is widespread in intestinal diseases involving ischemia and/or hypoxia. Since hypoxia alters stimulated Cl(−) and water flux, we investigated the influence of such a physiologically and pathophysiologically important signal on expression of the cystic fibrosis transmembrane conductance regu...

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Hlavní autoři: Zheng, Wen, Kuhlicke, Johannes, Jäckel, Kristian, Eltzschig, Holger K., Singh, Anurag, Sjöblom, Markus, Riederer, Brigitte, Weinhold, Cornelia, Seidler, Ursula, Colgan, Sean P., Karhausen, Jörn
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2009
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626614/
https://ncbi.nlm.nih.gov/pubmed/18779379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-110221
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