Overexpression of Pre-Pro-Cholecystokinin Stimulates β-Cell Proliferation in Mouse and Human Islets with Retention of Islet Function

Type 1 and type 2 diabetes result from a deficit in insulin production and β-cell mass. Methods to expand β-cell mass are under intensive investigation for the treatment of type 1 and type 2 diabetes. We tested the hypothesis that cholecystokinin (CCK) can promote β-cell proliferation. We treated is...

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Hauptverfasser: Lavine, Jeremy A., Raess, Philipp W., Davis, Dawn Belt, Rabaglia, Mary E., Presley, Brent K., Keller, Mark P., Beinfeld, Margery C., Kopin, Alan S., Newgard, Christopher B., Attie, Alan D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Endocrine Society 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626203/
https://ncbi.nlm.nih.gov/pubmed/18845673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0255
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