Cocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity

Repeated exposure to cocaine causes sensitized behavioral responses and increased dendritic spines on medium spiny neurons of the nucleus accumbens (NAc). We find that cocaine regulates myocyte enhancer factor 2 (MEF2) transcription factors to control these two processes in vivo. Cocaine suppresses...

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Hauptverfasser: Pulipparacharuvil, Suprabha, Renthal, William, Hale, Carly F., Taniguchi, Makoto, Xiao, Guanghua, Kumar, Arvind, Russo, Scott J., Sikder, Devanjan, Dewey, Colleen M., Davis, Maya M., Greengard, Paul, Nairn, Angus C., Nestler, Eric J., Cowan, Christopher W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626175/
https://ncbi.nlm.nih.gov/pubmed/18760698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.06.020
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