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Modulation of Minute Virus of Mice Cytotoxic Activities through Site-Directed Mutagenesis within the NS Coding Region

Late in infection, parvovirus minute virus of mice (MVMp) induces the lysis of mouse A9 fibroblasts. This effect depends on the large nonstructural phosphoprotein NS1, which plays in addition a major role in viral DNA replication and progeny particle production. Since the NS1 C-terminal region is su...

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Bibliographic Details
Published in:J Virol
Main Authors: Daeffler, Laurent, Hörlein, Rita, Rommelaere, Jean, Nüesch, Jürg P. F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2003
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262581/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14610171/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.23.12466-12478.2003
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