Quantifying Adenovirus-Neutralizing Antibodies by Luciferase Transgene Detection: Addressing Preexisting Immunity to Vaccine and Gene Therapy Vectors

The presence of various levels of anti-adenovirus serotype 5 (Ad5)-neutralizing antibodies in humans is thought to contribute to the inconsistent clinical results obtained so far in diverse gene transfer and vaccination studies and might preclude universal dosing with recombinant Ad5. Prescreening o...

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Autores principales: Sprangers, Mieke C., Lakhai, Wandena, Koudstaal, Wouter, Verhoeven, Marielle, Koel, Björn F., Vogels, Ronald, Goudsmit, Jaap, Havenga, Menzo J. E., Kostense, Stefan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Virology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC262545/
https://ncbi.nlm.nih.gov/pubmed/14605137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.41.11.5046-5052.2003
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