NMR Solution Structure of the Integral Membrane Enzyme DsbB – Functional Insights into DsbB Catalyzed Disulfide Bond Formation

We describe the first NMR structure of a polytopic helical membrane protein. DsbB, a bacterial cytoplasmic membrane protein, plays a key role in disulfide bond formation. It re-oxidizes DsbA, the periplasmic protein disulfide oxidant, using the oxidizing power of membrane-embedded quinones. We deter...

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Main Authors: Zhou, Yunpeng, Cierpicki, Tomasz, Flores Jimenez, Ricardo H., Lukasik, Stephen M., Ellena, Jeffrey F., Cafiso, David S., Kadokura, Hiroshi, Beckwith, Jon, Bushweller, John H.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2622435/
https://ncbi.nlm.nih.gov/pubmed/18922471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.08.028
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