Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: Targeting with a single chain antibody variable domain isolated by phage display

EGFRvIII is a mutant epidermal growth factor receptor found in glioblastoma, and in carcinoma of the breast, ovary, and lung. The mutant receptor has a deletion in its extracellular domain that results in the formation of a new, tumor-specific extracellular sequence. Mice were immunized with a synth...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Lorimer, Ian A. J., Keppler-Hafkemeyer, Andrea, Beers, Richard A., Pegram, Charles N., Bigner, Darell D., Pastan, Ira
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1996
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962138/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14815
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