Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus
Immature CD4(+)CD8(+) thymocytes expressing T-cell antigen receptors (TCR) are selected by TCR-mediated recognition of peptides associated with major histocompatibility complex molecules on thymic stromal cells. Selection ensures reactivity of the mature cells to foreign antigens and tolerance to se...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1996
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26207/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962126/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14747 |
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