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cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

cagA, a gene that codes for an immunodominant antigen, is present only in Helicobacter pylori strains that are associated with severe forms of gastroduodenal disease (type I strains). We found that the genetic locus that contains cagA (cag) is part of a 40-kb DNA insertion that likely was acquired h...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Censini, Stefano, Lange, Christina, Xiang, Zhaoying, Crabtree, Jean E., Ghiara, Paolo, Borodovsky, Mark, Rappuoli, Rino, Covacci, Antonello
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26189/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962108/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14648
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