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Free tyrosine and tyrosine-rich peptide-dependent superoxide generation catalyzed by a copper-binding, threonine-rich neurotoxic peptide derived from prion protein

Previously, generation of superoxide anion (O(2)(•-)) catalyzed by Cu-binding peptides derived from human prion protein (model sequence for helical Cu-binding motif VNITKQHTVTTTT was most active) in the presence of catecholamines and related aromatic monoamines such as phenylethylamine and tyramine,...

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Detalhes bibliográficos
Main Authors: Yokawa, Ken, Kagenishi, Tomoko, Goto, Kaishi, Kawano, Tomonori
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615546/
https://ncbi.nlm.nih.gov/pubmed/19158988
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