Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication

BACKGROUND: HIV-1 integrase (IN) is a key viral enzymatic molecule required for the integration of the viral cDNA into the genome. Additionally, HIV-1 IN has been shown to play important roles in several other steps during the viral life cycle, including reverse transcription, nuclear import and chr...

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Main Authors: Xu, Zaikun, Zheng, Yingfeng, Ao, Zhujun, Clement, Martin, Mouland, Andrew J, Kalpana, Ganjam V, Belhumeur, Pierre, Cohen, Éric A, Yao, XiaoJian
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615443/
https://ncbi.nlm.nih.gov/pubmed/19014595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-5-102
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