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Compromised proteasome degradation elevates neuronal nitric oxide synthase levels and induces apoptotic cell death
The significance of impairment of proteasome activity in PC12 cells was examined in connection with nitrative/nitrosative stress and apoptotic cell death. Treatment of differentiated PC12 cells with MG132, a proteasome inhibitor, elicited a dose- and time-dependent increase in neuronal nitric oxide...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614914/ https://ncbi.nlm.nih.gov/pubmed/18706882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.07.022 |
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