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Compromised proteasome degradation elevates neuronal nitric oxide synthase levels and induces apoptotic cell death

The significance of impairment of proteasome activity in PC12 cells was examined in connection with nitrative/nitrosative stress and apoptotic cell death. Treatment of differentiated PC12 cells with MG132, a proteasome inhibitor, elicited a dose- and time-dependent increase in neuronal nitric oxide...

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書目詳細資料
Main Authors: Lam, Philip Y., Cadenas, Enrique
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614914/
https://ncbi.nlm.nih.gov/pubmed/18706882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.07.022
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