Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may contribute to the decreased apoptosis that occurs in chronic lymphocytic leukemia (CLL), we assessed the expression levels of PDE isoforms in peripher...

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Detalhes bibliográficos
Main Authors: Zhang, Lingzhi, Murray, Fiona, Zahno, Anja, Kanter, Joan R., Chou, Daisy, Suda, Ryan, Fenlon, Michael, Rassenti, Laura, Cottam, Howard, Kipps, Thomas J., Insel, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614795/
https://ncbi.nlm.nih.gov/pubmed/19033455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806152105
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